MSI Controls
Microsatellite instability (MSI) is a molecular biomarker resulting from defects in the DNA mismatch repair (MMR) system, leading to alterations in microsatellite repeat lengths throughout the genome. MSI testing is widely used in colorectal, gastric, endometrial, and other cancers to support cancer characterization and identify patients who may benefit from targeted treatment approaches.
The MSI Controls contain formalin-fixed, paraffin-embedded (FFPE) curls with embedded cellular DNA exhibiting microsatellite instability. The MSI-H control contains instability at clinically relevant microsatellite loci commonly used for MSI assessment. These controls are designed for MSI assay development, validation, workflow monitoring, and routine quality control applications. The MSI-H control is formulated to contain approximately 16.7% MSI-H cellular content, providing a challenging reference material for assay verification, sensitivity assessment, and routine quality control applications.
| Cat. No. | Product Name | MSI-H Content | Price | Quantity | |
|---|---|---|---|---|---|
| D186-001 | MSI-H FFPE Control | 16.7% MSI | Login for Price | ||
| D186-000 | MSS FFPE Control | 0% MSI | Login for Price |
Microsatellite instability (MSI) is a molecular biomarker resulting from defects in the DNA mismatch repair (MMR) system, leading to alterations in microsatellite repeat lengths throughout the genome. MSI testing is widely used in colorectal, gastric, endometrial, and other cancers to support cancer characterization and identify patients who may benefit from targeted treatment approaches.
The MSI Controls contain formalin-fixed, paraffin-embedded (FFPE) curls with embedded cellular DNA exhibiting microsatellite instability. The MSI-H control contains instability at clinically relevant microsatellite loci commonly used for MSI assessment. These controls are designed for MSI assay development, validation, workflow monitoring, and routine quality control applications. The MSI-H control is formulated to contain approximately 16.7% MSI-H cellular content, providing a challenging reference material for assay verification, sensitivity assessment, and routine quality control applications.
Product Information
| Cat.No. | Product Name | MSI Content | Format |
|---|---|---|---|
| D186-001 | MSI-H FFPE Control | 16.7% MSI | FFPE curl |
| D186-000 | MSS FFPE Control | 0% MSI | FFPE curl |
MSI Marker Coverage
The MSI-H control contains instability at the following microsatellite markers and MSI-associated target loci:
BAT25, BAT26, NR21, NR24, MONO27, ACVR2A, BTBD7, DIDO1, MRE11, RYR3, SEC31A, SULF2, TGFBR2, BAX, RAD50, and CASP5.
Specifications
| Feature | Specification |
|---|---|
| Material | Cell-derived FFPE material |
| Format | Formalin-fixed, paraffin-embedded (FFPE) curl |
| Curl Thickness | 10 µm |
| Expected DNA Yield | ≥200 ng* |
| Storage | 2–8 °C |
| Intended Use | MSI assay validation, quality control, and workflow monitoring |
* Typical yield may vary depending on extraction method.
Key Features
- Cell-derived reference material
- FFPE format compatible with routine clinical laboratory workflows
- Suitable for assay validation and quality control applications
- MSI-High and MSS control options available
- Compatible with PCR- and NGS-based MSI testing workflows
Supports extraction, library preparation, sequencing, and data analysis workflow verification
Documents
Sample Certification (COA)
(The COA for your order will be enclosed within the shipping package.)
| Lot # | Certificate Type | Catalog Number(s) |
|---|---|---|
| 2605179 | Certificate Analysis | D186-000 |
| 2605175 | Certificate Analysis | D186-001 |
