The Extraction Controls are either ctDNA spiked in plasma at a fixed allele frequency (Panel 1) or wild-type cfDNA spiked in plasma at a fixed concentration (Panel 2). They are used as controls to help monitor cfDNA extraction efficiency from real human plasma, determine how low the absolute number of copies can be reliably extracted, and standardize the QC workflow for the cfDNA extraction process.
cfDNA fragments (~170bp) are mixed with full length genomic DNA background in real human plasma. The control is used for evaluating size specificity of cfDNA extraction by the extraction kit or method. A good cfDNA extraction method should preferentially extract the 170bp cfDNA only while excluding the full length chromosomal DNA.
Anchor Molecular offers a comprehensive collection of over 50 commonly observed RNA fusions, organized into eight multiplexed panels optimized for PCR- and NGS-based detection workflows. Each panel contains fusion RNAs at equal copy numbers, ensuring consistent and reliable performance across targets. Designed as a single, consistent, and flexible control source, Anchor Molecular’s Multiplexed RNA Fusion Panels help molecular labs, kit developers, and oncology researchers save time, reduce costs, and streamline regulatory validation.
Panels 6 and 7 include fusions frequently associated with hematologic cancers.
Panels 1, 2, 3, 4, 5, and 8 feature five to seven multiplexed fusions commonly found in solid tumors.
For broader applications, the Multiplexed RNA Fusion Mix v2 combines all solid tumor fusions into a single, convenient panel.
All panels are available as purified RNA in buffer or in FFPE format, supporting a wide range of research and diagnostic applications. For detailed information of each RNA fusion in each panel, here is the link.
We also offer individual RNA fusion controls and BCR-ABL1 panels, available under separate product categories.
For a free sample or to inquire about custom RNA fusions in human plasma or other formats, please contact us at info@anchormolecular.com or +1 925-400-9986 for quote.
AM Normal cfDNA-1: gDNA is nucleosomally fragmented from a popular normal male cell line
AM Normal cfDNA-2: gDNA is nucleosomally fragmented from normal female cell line
AM Normal cfDNA-3: gDNA is nucleosomally fragmented from pooled normal peripheral blood mononuclear cells (PBMC) from fresh blood
Please view "Description" tab below for product detail.
AM Normal cfDNA-1: DNA is extracted and fragmented from a popular normal male cell line
AM Normal cfDNA-2: DNA is extracted and fragmented from normal female cell line
AM Normal cfDNA-3: DNA is extracted and fragmented from pooled normal peripheral blood mononuclear cells (PBMC) from fresh blood
The POLE-POLD1 Mutation Controls contain formalin-fixed, paraffin-embedded (FFPE) slices with embedded cellular DNA carrying POLE mutations on Exon 9 (P286R), Exon 11 (F367S), Exon 13 (V411L, c.1231 G>C ) and Exon 14 (S459F ) and a POLD1 mutation on Exon 12 (S478N). All variants are present at an approximate 5% allele frequency and have been validated on the Idylla™ platform.
